What is Orfadin used for?
Orfadin is used to treat hereditary tyrosinemia type 1, a rare pediatric disease
causing progressive liver failure and liver cancer in young children. It is used along with a diet restricting the amino acids tyrosine and
Special Warnings with Orfadin:
Patients and their parents or caregivers should tell their doctor right away about:
- any unexplained eye symptoms (eye pain, redness, swelling or burning of the eyes)
- jaundice (yellowing of the skin and whites of the eyes, and dark color to the urine)
- excessive bleeding
What should I tell my health care provider?
- Tell your health care provider if you are trying to become pregnant, are already pregnant, or are breast-feeding.
- Tell your health care provider if you are allergic to nitisinone (Orfadin) or to any of the other ingredients in
- Tell your health care provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
What are some possible side effects of Orfadin? (This is NOT
a complete list of side effects reported with Orfadin. Your health care provider can
discuss with you a more complete list of side effects.)
The most common side effects of Orfadin were related to high tyrosine levels due to patients not eating the right foods as
well as rare cases of a decrease in platelet and white blood cell counts.
For more detailed information about Orfadin, ask your health care provider or pharmacist.